CELLULAR BIOLOGY OF NORMAL AND DISEASE STATES
This one-term course will explore the cellular basis of multiple disease states. The course, which meets twice a week (two hours each session), will be taught through both lecture and in class discussion of primary literature. Each of seven modules will examine normal cell biology and function and then define how defects in these processes lead to the spectrum of pathologies associated with each disease. Discussion of how bench top findings can be translated to treatments in the clinic will be facilitated by a diverse faculty that includes both basic and physician scientists. The seven modules are as follows: the first examines insulin secretion and signaling and how these events are perturbed in diabetes mellitus. The second module focuses on cell-cell adhesion and its role in cancer progression and epithelial barrier function. The third module defines how defects in endocytosis of the low-density lipoprotein receptor leads to hypercholesterolemia. The fourth analyzes the cellular basis of hypertension and how altered internalization of the epithelial sodium channel leads to elevated blood pressure. The fifth module investigates the role of apical membrane recycling and how defects in aquaporin-2 traffic leads to nephrogenic diabetes insipidus. The sixth module appraises the current state of our understanding of cystic fibrosis and how degradation of defective cystic fibrosis transmembrane conductance regulator by the quality control machinery in the endoplasmic reticulum and cell periphery leads to disease. The last module examines cell migration in wound healing and angiogenesis. At the end of the course students will have an increased understanding of normal cellular function and how research in cell biology can lead to a deeper understanding of diseases that impact millions of people each year.