REGULATION OF MEMBRANE TRAFFIC
Course analyzes membrane/protein traffic along both the biosynthetic & endocytic pathways. Emphasis placed on how this traffic is regulated. Topics include the role of g-proteins (both heterotrimetric & small), coat proteins (coatamer 1 & 2 & adaptors), signal transduction cascades (pkc, pka, ip3, etc.), & Snare complexes in protein trafficking. Also, we will discuss the role of the cytoskeleton in transporting cargo & signal transduction. Membrane traffic in several specialized cell types will be covered including polarized epithelial cells, cells of the immune system, & neurons.